(Generic) Acepromazine Injection
(Manufactured by: Boehringer Ingelheim)
Dose: 10mg
Quantity: 50 mL
Price: $45.18 USD
Description of (Generic) Acepromazine Injection
Uses
Acepromazine is a tranquilizer, most often used to sedate animals for minor procedures (e.g., nail trims), alleviate itching, and prevent vomiting due to motion sickness. It may also be used prior to anesthesia and surgery.
Dosage and Administration
The dosage should be individualized, depending upon the degree of tranquilization required. As a general rule, the dosage requirement in mg/lb of body weight decreases as the weight of the animal increases.
Acepromazine Maleate Injection may be given intravenously, intramuscularly or subcutaneously. The following schedule may be used as a guide to IV, IM or SC injections:
Dogs: 0.25-0.5 mg/lb of body weight.
Cats: 0.5-1 mg/lb of body weight.
Horses: 2-4 mg/100 lb of body weight.
IV doses should be administered slowly, and a period of at least 15 minutes should be allowed for the drug to take full effect
Contra-indications
Phenothiazines may potentiate the toxicity of organophosphates and the activity of procaine hydrochloride. Therefore, do not use Acepromazine Maleate Injection to control tremors associated with organic phosphate poisoning.
Do not use in conjunction with organophosphorus vermifuges or ectoparasiticides, including flea collars.
Do not use with procaine hydrochloride.
Pharmaceutical Precautions
Tranquilizers are potent central nervous system depressants and they can cause marked sedation with suppression of the sympathetic nervous system.
Tranquilizers can produce prolonged depression or motor restlessness when given in excessive amounts or when given to sensitive animals.
Tranquilizers are additive in action to the actions of other depressants and will potentiate general anesthesia. Tranquilizers should be administered in smaller doses and with greater care during general anesthesia and also to animals exhibiting symptoms of stress, debilitation, cardiac disease, sympathetic blockade, hypovolemia or shock. Acepromazine maleate, like other phenothiazine derivatives, is detoxified in the liver; therefore, it should be used with caution on animals with a previous history of liver dysfunction or leukopenia.
Hypotension can occur after rapid intravenous injection causing cardiovascular collapse.
Epinephrine is contraindicated for treatment of acute hypotension produced by phenothiazine-derivative tranquilizers since further depression of blood pressure can occur. Other pressor amines, such as norepinephrine or phenylephrine, are the drugs of choice.
In horses, paralysis of the retractor penis muscle has been associated with the use of phenothiazine-derivative tranquilizers. Such cases have occurred following the use of Acepromazine Maleate Injection. This risk should be duly considered prior to the administration to male horses (castrated and uncastrated). When given, the dosage should be carefully limited to the minimum necessary for the desired effect. At the time of tranquilization, it is not possible to differentiate between reversible protrusion of the penis (a normal clinical sign of narcosis) and the irreversible paralysis of the retractor muscle. The cause of this side reaction has not been determined. It has been postulated that such paralysis may occur when a tranquilizer is used in conjunction with testosterone (or in stallions).
Store at controlled room temperature, 59°-86°F (15° - 30°C).
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